Synergistic effects of D-arginine, D-methionine and D-histidine against <i>Porphyromonas gingivalis</i> biofilms
نویسندگان
چکیده
Porphyromonas gingivalis biofilms are implicated in the pathology of peri-implantitis and periodontitis. In this study, D-arginine (R), D-methionine (M), D-histidine (H), a mixture these D-amino acids (D-AAs) were investigated as an effective therapeutic strategy against P. biofilms. The bacterial growth activity minimum inhibitory concentrations determined for each D-AA, along with effects D-AAs on biofilm development, morphology, structure, extracellular polysaccharides (EPS), cytotoxicity towards commensals, structure. D-AA delayed proliferation gingivalis, changed its membrane decreased thickness integrity, compared individual D-AAs. EPS content increased concentration present study shows that 4 mM RMH, triple mixture, enhanced deleterious without any D-AAs, thus providing new treatment
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ژورنال
عنوان ژورنال: Biofouling
سال: 2021
ISSN: ['0892-7014', '1026-7867', '1029-2454']
DOI: https://doi.org/10.1080/08927014.2021.1893309